Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25266945 | 1.00 | HDAC6 (0.45) | HDAC6HDAC1ADRA2AADRA2BADRA2C | |
| SCHEMBL25267699 | 0.89 | HDAC6 (0.46) | HDAC6HDAC1ADRA2AADRA2BADRA2C | |
| SCHEMBL25246229 | 0.87 | HDAC6 (0.49) | HDAC6HDAC1ADRA2AADRA2BADRA2C | |
| SCHEMBL30425501 | 0.87 | HDAC6 (0.49) | HDAC6HDAC1ADRA2AADRA2BADRA2C | |
| SCHEMBL25222486 | 0.86 | HDAC1 (0.42) | HDAC6HDAC1ADRA2AADRA2BADRA2C | |
| SCHEMBL25217536 | 0.85 | HDAC6 (0.38) | HDAC6HDAC1ADRA2AADRA2BADRA2C | |
| SCHEMBL25252684 | 0.85 | HDAC6 (0.43) | HDAC6ADRA2AADRA2BADRA2C | |
| SCHEMBL25223945 | 0.84 | HDAC6 (0.44) | HDAC6HDAC1ADRA2AADRA2BADRA2C | |
| SCHEMBL30425792 | 0.84 | HDAC6 (0.44) | HDAC6HDAC1ADRA2AADRA2BADRA2C | |
| SCHEMBL25207947 | 0.83 | ADRA2A (0.35) | HDAC6HDAC1ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | claimed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | claimed |
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | disclosed |