Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16975513 | 1.00 | IRAK4 (0.41) | IRAK4MAPK8MAPK9MAPK10JAK1 | |
| SCHEMBL16975451 | 0.91 | IRAK4 (0.35) | IRAK4MAPK8MAPK9MAPK10JAK1 | |
| SCHEMBL10191777 | 0.89 | IRAK4 (0.38) | IRAK4JAK1KDM5A | |
| SCHEMBL15134755 | 0.87 | KDM5A (0.41) | KDM5AL3MBTL3L3MBTL1 | |
| SCHEMBL1422774 | 0.85 | MET (0.41) | IRAK4JAK1KDM5A | |
| Hydrochloric Acid SCHEMBL15875304 | 0.83 | MET (0.42) | IRAK4JAK1KDM5A | |
| Hydrochloric Acid SCHEMBL16593449 | 0.83 | MET (0.42) | IRAK4JAK1KDM5A | |
| SCHEMBL173506 | 0.83 | — | — | |
| SCHEMBL17076755 | 0.81 | LRRK2 (0.42) | KDM5A | |
| Hydrochloric Acid SCHEMBL25243994 | 0.81 | PIK3CD (0.41) | KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436970-A1 | PYRAZOLOTRIAZINE DERIVATIVES USEFUL AS CDK9 INHIBITORS | Origenis GmbH (DE) | 2024-10-02 | — | — | EP | disclosed |
| CN-118284610-A | Pyrazolotriazine derivatives as CDK9 inhibitors | 原真股份有限公司 | 2024-07-02 | — | — | CN | disclosed |
| WO-2023094310-A1 | PYRAZOLOTRIAZINE DERIVATIVES USEFUL AS CDK9 INHIBITORS | ORIGENIS GMBH (DE) | 2023-06-01 | — | — | WO | disclosed |