Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 9/20 | 0.71 |
| ▸ | TNF | P01375 | 1/20 | 0.67 |
| ▸ | NLRP3 | Q96P20 | 10/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25195389 | 1.00 | IL1B (0.71) | IL1BTNFNLRP3KCNH2 | |
| SCHEMBL25854958 | 0.89 | IL1B (0.71) | IL1BTNFNLRP3 | |
| SCHEMBL25861500 | 0.89 | IL1B (0.71) | IL1BTNFNLRP3 | |
| SCHEMBL25258966 | 0.89 | IL1B (0.71) | IL1BTNFNLRP3 | |
| SCHEMBL30833885 | 0.87 | IL1B (0.72) | IL1BTNFNLRP3 | |
| SCHEMBL31681927 | 0.85 | IL1B (0.70) | IL1BTNFNLRP3 | |
| SCHEMBL22654972 | 0.83 | IL1B (1.00) | IL1BTNFNLRP3 | |
| SCHEMBL22689607 | 0.83 | IL1B (1.00) | IL1BTNFNLRP3 | |
| SCHEMBL22654986 | 0.83 | IL1B (1.00) | IL1BTNFNLRP3 | |
| SCHEMBL22689606 | 0.83 | IL1B (1.00) | IL1BTNFNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433459-A1 | PYRIDAZINE DERIVATIVES AS INHIBITORS OF NLRP3 | F. Hoffmann-La Roche AG (CH) | 2024-09-25 | — | — | EP | claimed |
| CN-118265701-A | Pyridazine derivatives as inhibitors of NLRP3 | 豪夫迈·罗氏有限公司 | 2024-06-28 | — | — | CN | claimed |
| WO-2023088987-A1 | PYRIDAZINE DERIVATIVES AS INHIBITORS OF NLRP3 | F. HOFFMANN-LA ROCHE AG (CH) | 2023-05-25 | — | — | WO | claimed |
| EP-4433459-A1 | PYRIDAZINE DERIVATIVES AS INHIBITORS OF NLRP3 | F. Hoffmann-La Roche AG (CH) | 2024-09-25 | — | — | EP | disclosed |
| CN-118265701-A | Pyridazine derivatives as inhibitors of NLRP3 | 豪夫迈·罗氏有限公司 | 2024-06-28 | — | — | CN | disclosed |
| WO-2023088987-A1 | PYRIDAZINE DERIVATIVES AS INHIBITORS OF NLRP3 | F. HOFFMANN-LA ROCHE AG (CH) | 2023-05-25 | — | — | WO | disclosed |