Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | FABP6 | P51161 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853383 | 0.93 | ALDH1A1 (0.54) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL11342856 | 0.85 | ALDH1A1 (0.61) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL31451604 | 0.83 | ALDH1A1 (0.44) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL31451292 | 0.83 | ALDH1A1 (0.44) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL24286432 | 0.79 | ALDH1A1 (0.46) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL9799216 | 0.79 | ALDH1A1 (0.54) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL4125499 | 0.79 | ALDH1A1 (0.46) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL9617547 | 0.79 | ALDH1A1 (0.54) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL21603157 | 0.79 | ALDH1A1 (0.54) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL29221775 | 0.77 | ALDH1A1 (0.45) | ALDH1A1GAAHSD17B10MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000490-B2 | Inhibitors of the fibroblast growth factor receptor | BLUEPRINT MEDICINES CORPORATION (US) | 2018-06-19 | — | — | US | disclosed |
| US-10000490-B2 | Inhibitors of the fibroblast growth factor receptor | BLUEPRINT MEDICINES CORPORATION (US) | 2018-06-19 | — | — | US | disclosed |
| US-20170253593-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION | 2017-09-07 | — | — | US | disclosed |
| US-20170253593-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION | 2017-09-07 | — | — | US | disclosed |
| US-9695165-B2 | Inhibitors of the fibroblast growth factor receptor | BLUEPRINT MEDICINES CORPORATION (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695165-B2 | Inhibitors of the fibroblast growth factor receptor | BLUEPRINT MEDICINES CORPORATION (US) | 2017-07-04 | — | — | US | disclosed |
| WO-2015108992-A1 | HETEROBICYCLIC COMPOUNDS AND THEIR USE AS FGFR4 RECEPTOR INHIBITORS | BLUEPRINT MEDICINES CORPORATION (US) | 2015-07-23 | — | — | WO | disclosed |
| WO-2015108992-A1 | HETEROBICYCLIC COMPOUNDS AND THEIR USE AS FGFR4 RECEPTOR INHIBITORS | BLUEPRINT MEDICINES CORPORATION (US) | 2015-07-23 | — | — | WO | disclosed |
| US-20150197519-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION (US) | 2015-07-16 | — | — | US | disclosed |
| US-20150197519-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION (US) | 2015-07-16 | — | — | US | disclosed |
| US-8093238-B2 | Fused thiazole derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2012-01-10 | — | — | US | disclosed |
| US-20100069361-A1 | Fused Thiazole Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-03-18 | — | — | US | disclosed |
| EP-2076512-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008044022-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253593-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | FGFR4, FGFR1, FGFR2 | ALDH1A1 2337/4885GAA 1114/4885HSD17B10 2702/4885 |
| US-20100069361-A1 | Fused Thiazole Derivatives as Kinase Inhibitors | JAK1, MTOR, MOK | ALDH1A1 1714/4885GAA 1343/4885HSD17B10 2961/4885 |
| US-10000490-B2 | Inhibitors of the fibroblast growth factor receptor | FGFR4, FGFR1, FGFR2 | ALDH1A1 2337/4885GAA 1114/4885HSD17B10 2702/4885 |
| US-20150197519-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | FGFR4, FGFR1, FGFR2 | ALDH1A1 2337/4885GAA 1114/4885HSD17B10 2702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.