Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26030212 | 0.77 | CDK8 (0.46) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL26120074 | 0.77 | NPSR1 (0.44) | DYRK1AADORA3 | |
| SCHEMBL15494745 | 0.74 | CDK8 (0.46) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL4546562 | 0.74 | CDK8 (0.53) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL27944394 | 0.74 | CDK8 (0.43) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL26121877 | 0.71 | PRMT5 (0.30) | — | |
| SCHEMBL2913127 | 0.70 | CDK8 (0.49) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL30430738 | 0.68 | TBXAS1 (0.47) | — | |
| SCHEMBL334306 | 0.67 | CDK8 (0.53) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL21352246 | 0.67 | CDK8 (0.53) | CDK8ROCK1CHEK1MAP4K4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023044171-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2023-03-23 | — | — | WO | disclosed |