Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | GSR | P00390 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.47 |
| ▸ | ARG2 | P78540 | 4/20 | 0.47 |
| ▸ | ARG1 | P05089 | 3/20 | 0.47 |
| ▸ | NOS2 | P35228 | 6/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548650 | 0.87 | GSR (0.53) | GSRDDAH1ARG2ARG1NOS2 | |
| SCHEMBL43621 | 0.87 | GSR (0.53) | GSRDDAH1ARG2ARG1NOS2 | |
| SCHEMBL29485083 | 0.86 | GSR (0.61) | GSRBLMDDAH1ARG2ARG1 | |
| Water SCHEMBL380639 | 0.85 | GSR (0.52) | GSRDDAH1ARG2ARG1NOS2 | |
| SCHEMBL13747854 | 0.85 | GSR (0.55) | GSRBLMDDAH1ARG2ARG1 | |
| SCHEMBL11579098 | 0.85 | GSR (0.55) | GSRBLMDDAH1ARG2ARG1 | |
| SCHEMBL28717409 | 0.84 | ARG2 (0.50) | GSRDDAH1ARG2ARG1NOS2 | |
| SCHEMBL826660 | 0.84 | GSR (0.50) | GSRBLMKMT2ADDAH1ARG2 | |
| SCHEMBL10583206 | 0.81 | GSR (0.55) | GSRBLMDDAH1ARG2ARG1 | |
| SCHEMBL13005399 | 0.81 | GSR (0.55) | GSRBLMDDAH1ARG2ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4176050-A1 | PYRROLYSYL-TRNA SYNTHETASE VARIANTS AND USES THEREOF | enGenes Biotech GmbH (AT) | 2023-05-10 | — | — | EP | disclosed |