SCHEMBL30433748

SCHEMBL30433748

FC(F)(F)c1cnc(Cl)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3R1 P27986 1/20 0.38
PIK3CA P42336 1/20 0.38
ASPH Q12797 1/20 0.36
NOTUM Q6P988 4/20 0.36
PIK3CD O00329 1/20 0.36
MBOAT4 Q96T53 1/20 0.35
ALDH1A1 P00352 2/20 0.35
KCNQ3 O43525 2/20 0.35
KCNQ2 O43526 2/20 0.35
KCNE1 P15382 2/20 0.35
KCNQ1 P51787 2/20 0.35
KMO O15229 2/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
JUN P05412 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
PLAU P00749 1/20 0.33
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1471015 1.00 PIK3R1 (0.38) PIK3R1PIK3CAASPHNOTUMPIK3CD
SCHEMBL3840400 0.84 PIK3R1 (0.42) PIK3R1PIK3CAASPHNOTUMPIK3CD
SCHEMBL31280670 0.83 RXRA (0.31) PIK3R1PIK3CAALDH1A1
SCHEMBL1515470 0.82 PIK3R1 (0.41) PIK3R1PIK3CANOTUMPIK3CDALDH1A1
SCHEMBL29435663 0.82 PIK3R1 (0.41) PIK3R1PIK3CANOTUMPIK3CDALDH1A1
SCHEMBL1470507 0.79 TSHR (0.43)
SCHEMBL30833531 0.79 TSHR (0.43)
SCHEMBL19616271 0.78 PIK3CD (0.38) ASPHNOTUMPIK3CDMBOAT4ALDH1A1
SCHEMBL22557297 0.78 PIK3CD (0.49) PIK3R1PIK3CAPIK3CDMBOAT4ALDH1A1
SCHEMBL432680 0.78 PIK3R1 (0.36) PIK3R1PIK3CAASPHNOTUMPIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119912387-A Amide compound and/or salt thereof and application thereof 帕潘纳(北京)科技有限公司 2025-05-02 CN disclosed
CN-111655700-B Oxadiazolopyridine derivatives as ghrelin O-acyltransferase (GOAT) inhibitors 勃林格殷格翰国际有限公司 2023-07-18 CN disclosed
CN-110869017-B Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof 英安塔制药有限公司 2023-05-05 CN disclosed