Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30433880 | 0.79 | ADORA2A (0.37) | ADORA2AADORA1AXLMKNK1MKNK2 | |
| SCHEMBL25176771 | 0.71 | AXL (0.35) | ADORA2AADORA1AXLMKNK1MKNK2 | |
| SCHEMBL11316439 | 0.66 | DYRK1A (0.34) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL20674132 | 0.65 | AXL (0.34) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL13182502 | 0.65 | AXL (0.34) | ADORA2AADORA1AXLMKNK1MKNK2 | |
| SCHEMBL6290090 | 0.65 | MEN1 (0.47) | ADORA2AADORA1ADORA2BSMN1; SMN2NPC1 | |
| SCHEMBL25172345 | 0.64 | PDPK1 (0.37) | NPC1PDPK1PARP1 | |
| SCHEMBL5334843 | 0.64 | ADORA2A (0.50) | ADORA2AADORA1AXLMKNK1MKNK2 | |
| SCHEMBL10740688 | 0.63 | ALDH1A1 (0.38) | ADORA2AADORA1AXLMKNK1MKNK2 | |
| SCHEMBL13778445 | 0.63 | AXL (0.48) | ADORA2AADORA1AXLMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426702-A1 | CONDENSED-PYRAZINE AMINE DERIVATIVES FOR TREATING SCA3 | Skyhawk Therapeutics, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023081858-A1 | CONDENSED-PYRAZINE AMINE DERIVATIVES FOR TREATING SCA3 | SKYHAWK THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |