Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.31 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887207 | 0.86 | PIK3CA (0.37) | CSNK2A2CSNK2BCSNK2A1CDK1CCNB1 | |
| SCHEMBL23887120 | 0.85 | CCNE2 (0.33) | CDK1CCNB1CCNE2CDK4CCND1 | |
| SCHEMBL23887048 | 0.81 | PIK3CA (0.34) | CDK1CCNB1CCNE2CDK4CCND1 | |
| SCHEMBL23886987 | 0.81 | SIRT2 (0.56) | SIRT2MAOBCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL23887280 | 0.81 | GPR35 (0.35) | CDK1CCNB1CCNE2CDK4CCND1 | |
| SCHEMBL30564411 | 0.80 | CCNE2 (0.31) | CDK1CCNB1CCNE2CDK4CCND1 | |
| SCHEMBL30768042 | 0.79 | KDM4E (0.34) | CDK1CCNB1CCNE2CDK4CCND1 | |
| SCHEMBL30564466 | 0.75 | MAOB (0.38) | SIRT2MAOBCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL30564356 | 0.73 | CCNE2 (0.32) | CDK1CCNB1CCNE2CDK4CCND1 | |
| SCHEMBL23887343 | 0.73 | PIK3CA (0.37) | CSNK2A2CSNK2BCSNK2A1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136568-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PI3KALPHA INHIBITORS | NANJING ZENSHINE PHARMACEUTICALS CO., LTD. (CN) | 2025-05-01 | — | — | US | disclosed |
| EP-4444714-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PI3KALPHA INHIBITORS | Nanjing Zenshine Pharmaceuticals Co., Ltd. (CN) | 2024-10-16 | — | — | EP | disclosed |
| CN-118742545-A | Fused heterocyclic compounds as PI3K alpha inhibitors | 南京征祥医药有限公司 | 2024-10-01 | — | — | CN | disclosed |
| WO-2023104111-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PI3KALPHA INHIBITORS | NANJING ZENSHINE PHARMACEUTICALS CO., LTD. (CN) | 2023-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136568-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PI3KALPHA INHIBITORS | PIK3CA, PIK3CD, PIK3CB | SIRT2 2869/4885MAOB 1788/4885CSNK2A2 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.