Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 7/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.43 |
| ▸ | PRKX | P51817 | 3/20 | 0.43 |
| ▸ | PRKACA | P17612 | 5/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.41 |
| ▸ | PRKACG | P22612 | 4/20 | 0.41 |
| ▸ | PRKACB | P22694 | 4/20 | 0.41 |
| ▸ | MYLK | Q15746 | 4/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | MARK3 | P27448 | 2/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23795383 | 1.00 | ROCK1 (0.43) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL30438729 | 1.00 | ROCK1 (0.43) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL23795416 | 1.00 | ROCK1 (0.43) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| Hydrochloric Acid SCHEMBL30439409 | 0.99 | ROCK2 (0.43) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| Hydrochloric Acid SCHEMBL23795343 | 0.99 | ROCK2 (0.43) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| Hydrochloric Acid SCHEMBL30439412 | 0.99 | ROCK2 (0.43) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| Hydrochloric Acid SCHEMBL23795384 | 0.99 | ROCK2 (0.43) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL23795312 | 0.87 | ROCK1 (0.42) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL23795330 | 0.87 | ROCK1 (0.42) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL30439350 | 0.87 | ROCK1 (0.42) | ROCK1ROCK2PRKCDPRKCEPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116555-B | Rho kinase inhibitor and preparation method and application thereof | 北京盈科瑞创新药物研究有限公司 | 2023-06-02 | — | — | CN | disclosed |