Known targets — ChEMBL curated mechanism
CDK1CDK10CDK11BCDK12CDK13CDK14CDK15CDK16CDK17CDK18CDK19CDK2CDK20CDK3CDK4CDK5CDK6CDK7CDK8CDK9
The experimentally established mechanism targets of At-7519. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 known ✓ | P24941 | 7/20 | 1.00 |
| ▸ | CDK4 known ✓ | P11802 | 2/20 | 1.00 |
| ▸ | CDK5 known ✓ | Q00535 | 2/20 | 1.00 |
| ▸ | CDK14 known ✓ | O94921 | 14/20 | 0.86 |
| ▸ | CDK1 known ✓ | P06493 | 2/20 | 0.86 |
| ▸ | CDK11B known ✓ | P21127 | 1/20 | 0.86 |
| ▸ | CDK7 known ✓ | P50613 | 1/20 | 0.86 |
| ▸ | CDK9 known ✓ | P50750 | 1/20 | 0.86 |
| ▸ | CDK3 known ✓ | Q00526 | 1/20 | 0.86 |
| ▸ | CDK6 known ✓ | Q00534 | 1/20 | 0.86 |
| ▸ | CDK16 known ✓ | Q00536 | 1/20 | 0.86 |
| ▸ | CDK17 known ✓ | Q00537 | 1/20 | 0.86 |
| ▸ | CDK18 known ✓ | Q07002 | 1/20 | 0.86 |
| ▸ | CDK13 known ✓ | Q14004 | 1/20 | 0.86 |
| ▸ | CDK15 known ✓ | Q96Q40 | 1/20 | 0.86 |
| ▸ | CDK19 known ✓ | Q9BWU1 | 1/20 | 0.86 |
| ▸ | CDK12 known ✓ | Q9NYV4 | 1/20 | 0.86 |
| ▸ | CCNY | Q8ND76 | 13/20 | 0.86 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.86 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| At-7519 SCHEMBL21134171 | 0.93 | CDK2 (1.00) | CDK2CDK4CDK5CDK14CCNY | |
| At-7519 SCHEMBL29686205 | 0.92 | CDK2 (0.98) | CDK2CDK4CDK5CDK14CCNY | |
| At-7519 SCHEMBL29369459 | 0.88 | CDK14 (0.90) | CDK2CDK4CDK5CDK14CCNY | |
| SCHEMBL17252164 | 0.77 | CDK14 (0.70) | CDK2CDK4CDK5CDK14CCNY | |
| At-7519 SCHEMBL955568 | 0.74 | CDK5 (0.67) | CDK2CDK4CDK5CDK14CCNY | |
| At-7519 SCHEMBL31046986 | 0.74 | CDK5 (0.66) | CDK2CDK4CDK5CDK14CCNY | |
| At-7519 SCHEMBL953647 | 0.74 | CDK5 (0.66) | CDK2CDK4CDK5CDK14CCNY | |
| At-7519 SCHEMBL1069453 | 0.73 | CDK5 (0.62) | CDK2CDK4CDK5CDK14CCNY | |
| SCHEMBL22594270 | 0.73 | CDK14 (0.59) | CDK2CDK4CDK5CDK14CCNY | |
| SCHEMBL30915451 | 0.71 | CDK5 (0.60) | CDK2CDK4CDK5CDK14CCNY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293414-A1 | USE OF CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS FOR THE SLOWDOWN OR PREVENTION OF BIOLOGICAL AGING | HOPE PERMANENTE LLC (US) | 2023-09-21 | — | — | US | disclosed |
| EP-4192463-A1 | USE OF CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS FOR THE SLOWDOWN OR PREVENTION OF BIOLOGICAL AGING | Hope Permanente, LLC (US) | 2023-06-14 | — | — | EP | disclosed |