Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 9/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.45 |
| ▸ | PRKX | P51817 | 3/20 | 0.45 |
| ▸ | PRKACA | P17612 | 6/20 | 0.42 |
| ▸ | PRKACG | P22612 | 5/20 | 0.42 |
| ▸ | PRKACB | P22694 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.42 |
| ▸ | PRKCG | P05129 | 3/20 | 0.42 |
| ▸ | PRKCB | P05771 | 3/20 | 0.42 |
| ▸ | PRKCA | P17252 | 3/20 | 0.42 |
| ▸ | PRKCH | P24723 | 3/20 | 0.42 |
| ▸ | PRKCI | P41743 | 3/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23795411 | 1.00 | ROCK1 (0.45) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL23795287 | 1.00 | ROCK1 (0.45) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL30439172 | 1.00 | ROCK1 (0.45) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL23795286 | 1.00 | ROCK1 (0.45) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| Hydrochloric Acid SCHEMBL23795300 | 0.99 | ROCK2 (0.45) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| Hydrochloric Acid SCHEMBL30439360 | 0.99 | ROCK2 (0.45) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| Hydrochloric Acid SCHEMBL23795302 | 0.99 | ROCK2 (0.45) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| Hydrochloric Acid SCHEMBL30439401 | 0.99 | ROCK2 (0.45) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL23795417 | 0.88 | PRKCD (0.55) | ROCK1ROCK2PRKCDPRKCEPRKD1 | |
| SCHEMBL23795321 | 0.88 | PRKCD (0.55) | ROCK1ROCK2PRKCDPRKCEPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116555-B | Rho kinase inhibitor and preparation method and application thereof | 北京盈科瑞创新药物研究有限公司 | 2023-06-02 | — | — | CN | disclosed |