Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 15/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ASPH | Q12797 | 1/20 | 0.49 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.49 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21045700 | 1.00 | TRPC6 (0.54) | TRPC6KDM4EASPHRIOX2KDM8 | |
| SCHEMBL21085409 | 0.91 | TRPC6 (0.47) | TRPC6TTR | |
| SCHEMBL21045627 | 0.91 | TTR (0.57) | TRPC6TTR | |
| SCHEMBL21045884 | 0.90 | TRPC6 (0.54) | TRPC6 | |
| SCHEMBL21045670 | 0.90 | TRPC6 (0.56) | TRPC6 | |
| SCHEMBL21081280 | 0.89 | TRPC6 (0.48) | TRPC6KDM4EP4HTM | |
| SCHEMBL21045707 | 0.88 | TRPC6 (0.57) | TRPC6 | |
| SCHEMBL21045671 | 0.86 | TRPC6 (0.58) | TRPC6 | |
| SCHEMBL21045708 | 0.86 | MEN1 (0.45) | TRPC6 | |
| SCHEMBL21045625 | 0.86 | TRPC6 (0.56) | TRPC6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527078-B | Pyridinecarbonyl derivatives and their therapeutic use as TRPC6 inhibitors | 勃林格殷格翰国际公司 | 2023-06-02 | — | — | CN | disclosed |