Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL591059 | 0.83 | HCAR2 (0.44) | HCAR2KDM4ECYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL4446514 | 0.82 | HCAR2 (0.33) | HCAR2KDM4ECYP2C19HSD17B10LMNA | |
| SCHEMBL9956509 | 0.82 | HCAR2 (0.33) | HCAR2KDM4ECYP2C19HSD17B10LMNA | |
| SCHEMBL1018503 | 0.82 | KDM4E (0.46) | HCAR2KDM4ECYP2C19HSD17B10LMNA | |
| SCHEMBL27432771 | 0.79 | HCAR2 (0.33) | HCAR2KDM4ECYP2C19HSD17B10LMNA | |
| SCHEMBL948133 | 0.79 | HCAR2 (0.42) | HCAR2KDM4E | |
| SCHEMBL27320966 | 0.79 | HCAR2 (0.32) | HCAR2KDM4ECYP2C19HSD17B10LMNA | |
| SCHEMBL948061 | 0.77 | HCAR2 (0.36) | HCAR2LMNAPTGDR2ALDH1A1 | |
| SCHEMBL4878445 | 0.76 | HCAR2 (0.47) | HCAR2KDM4ELMNAMAPTCYP1A2 | |
| SCHEMBL947154 | 0.76 | HCAR2 (0.45) | HCAR2KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243777-A1 | Method for manufacturing Pyridyl-substituted pyrazoles | Bayer CropScience AG (DE) | 2010-10-27 | — | — | EP | disclosed |
| CN-101087763-A | Therapeutic agents | ASTRAZENECA AB (SE) | 2007-12-12 | — | — | CN | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |