Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 10/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4878445 | 0.89 | HCAR2 (0.47) | HCAR2HCAR3KDM4EHAO1 | |
| SCHEMBL948543 | 0.88 | HCAR2 (0.46) | HCAR2HCAR3HAO1 | |
| SCHEMBL591059 | 0.86 | HCAR2 (0.44) | HCAR2HCAR3KDM4EHAO1 | |
| SCHEMBL11365602 | 0.86 | HCAR2 (0.48) | HCAR2HCAR3HAO1 | |
| SCHEMBL27432771 | 0.81 | HCAR2 (0.33) | HCAR2KDM4E | |
| SCHEMBL824999 | 0.81 | KDM4E (0.44) | KDM4E | |
| SCHEMBL30420119 | 0.80 | IKBKB (0.36) | HCAR2 | |
| SCHEMBL3044296 | 0.79 | HCAR2 (0.37) | HCAR2KDM4E | |
| SCHEMBL1018503 | 0.77 | KDM4E (0.46) | HCAR2PTPN11KDM4E | |
| SCHEMBL4446514 | 0.77 | HCAR2 (0.33) | HCAR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451450-B1 | Inhibitors of proline racemase enzymes for the treatment of Trypanosoma spp infections | PASTEUR INSTITUT (FR) | 2014-07-02 | — | — | EP | disclosed |
| EP-2451450-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | Institut Pasteur (FR) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011004323-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | INSTITUT PASTEUR (FR) | 2011-01-13 | — | — | WO | disclosed |
| EP-2272510-A1 | Inhibitors of the proline racemase of trypanosoma cruzi | Institut Pasteur (FR) | 2011-01-12 | — | — | EP | disclosed |