Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.37 |
| ▸ | SPTLC1 | O15269 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25202089 | 1.00 | PIK3CD (0.39) | PIK3CDDDB1CRBNCREBBPSPTLC1 | |
| SCHEMBL30442893 | 0.94 | DDB1 (0.36) | PIK3CDDDB1CRBNMKNK1NR1H2 | |
| SCHEMBL30442979 | 0.88 | DDB1 (0.38) | PIK3CDDDB1CRBNMKNK1NR1H2 | |
| SCHEMBL25236301 | 0.88 | DDB1 (0.38) | PIK3CDDDB1CRBNMKNK1NR1H2 | |
| SCHEMBL16210129 | 0.80 | DDB1 (0.41) | DDB1CRBNCREBBPSPTLC1BRD4 | |
| SCHEMBL31346312 | 0.78 | JAK2 (0.39) | PIK3CDNR1H2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL31623586 | 0.77 | MAPT (0.38) | PIK3CDMKNK1NR1H2PIK3CAPIK3CB | |
| SCHEMBL31623665 | 0.76 | GPR119 (0.38) | — | |
| SCHEMBL31399617 | 0.76 | GPR119 (0.36) | PIK3CD | |
| SCHEMBL34461310 | 0.74 | DDB1 (0.41) | DDB1CRBNCREBBPBRD4NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119053601-A | Small molecule inhibitors of ubiquitin-specific protease 1 (USP 1) and uses thereof | 英矽智能科技知识产权有限公司 | 2024-11-29 | — | — | CN | disclosed |
| EP-4430050-A1 | SMALL MOLECULE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) AND USES THEREOF | Insilico Medicine IP Limited (HK) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023083286-A1 | SMALL MOLECULE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-19 | — | — | WO | disclosed |