Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30443449 | 0.79 | ALDH1A1 (0.48) | BRD4KDM4EMAPK1HTTMET | |
| SCHEMBL30675016 | 0.74 | BRD4 (0.56) | BRD4BRD2BRD3BAZ2BBAZ2A | |
| SCHEMBL28769241 | 0.69 | KDM4E (0.55) | ROCK2ROCK1CDC42BPBKDM4ENPC1 | |
| SCHEMBL11655281 | 0.68 | GSK3B (0.47) | BRD4KDM4EMAPTTHRBMAPK1 | |
| SCHEMBL31127913 | 0.66 | CLK1 (0.59) | KDM4ENPC1LMNAPOLBMAPT | |
| SCHEMBL11258541 | 0.66 | CLK1 (0.59) | KDM4ENPC1LMNAPOLBMAPT | |
| SCHEMBL16650475 | 0.66 | BRD4 (1.00) | BRD4MET | |
| SCHEMBL30109099 | 0.66 | BRD4 (0.46) | BRD4KDM4ELMNAPOLBBLM | |
| SCHEMBL29848915 | 0.66 | BRD4 (1.00) | BRD4MET | |
| SCHEMBL16651370 | 0.66 | BRD4 (0.50) | BRD4KDM4EAPAF1NPC1KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4188551-A1 | ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF | Bayer Aktiengesellschaft (DE) | 2023-06-07 | — | — | EP | claimed |