Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 6/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168390 | 1.00 | KDM4E (0.38) | KDM4EALOX15L3MBTL1SRCMAP2K1 | |
| SCHEMBL20168391 | 1.00 | KDM4E (0.38) | KDM4EALOX15L3MBTL1SRCMAP2K1 | |
| SCHEMBL20168202 | 0.80 | S1PR2 (0.35) | KDM4EALOX15L3MBTL1AR | |
| SCHEMBL286524 | 0.80 | SRC (0.40) | KDM4ESRCMAP2K1EGFRERBB2 | |
| SCHEMBL30445237 | 0.80 | S1PR2 (0.35) | KDM4EALOX15L3MBTL1AR | |
| SCHEMBL20168200 | 0.80 | S1PR2 (0.35) | KDM4EALOX15L3MBTL1AR | |
| SCHEMBL20168026 | 0.80 | FGFR4 (0.44) | KDM4ESRCMAP2K1FGFR4EGFR | |
| SCHEMBL17714529 | 0.79 | SRC (0.39) | SRCMAP2K1FGFR4EGFRERBB2 | |
| SCHEMBL21749951 | 0.74 | ALDH1A1 (0.47) | KDM4EALOX15L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21749950 | 0.74 | ALDH1A1 (0.47) | KDM4EALOX15L3MBTL1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139862-B | Substituted bicyclic heterocyclic derivatives useful as ROMK channel inhibitors | 百时美施贵宝公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-110678463-B | Substituted nitrogen-containing compounds | 百时美施贵宝公司 | 2023-06-06 | — | — | CN | disclosed |