Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | FSHR | P23945 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26151941 | 1.00 | GSK3B (0.38) | GSK3BMAPTATRGSK3ASCN10A | |
| SCHEMBL30418001 | 0.89 | TRPV1 (0.38) | GSK3BMAPTATRSCN10ATSHR | |
| SCHEMBL26152155 | 0.89 | TRPV1 (0.38) | GSK3BMAPTATRSCN10ATSHR | |
| SCHEMBL25184331 | 0.89 | CDK9 (0.38) | GSK3BMAPTATRGSK3ASCN10A | |
| SCHEMBL30419312 | 0.86 | ATR (0.37) | ATRSCN10ATSHRFSHRACACB | |
| SCHEMBL30417617 | 0.84 | CDK9 (0.36) | ATRSCN10ATSHRFSHRSYK | |
| SCHEMBL31058907 | 0.84 | CDK9 (0.36) | ATRSCN10ATSHRFSHRSYK | |
| SCHEMBL30419779 | 0.84 | IDH1 (0.37) | ATRSCN10ATSHRFSHRSYK | |
| SCHEMBL26152171 | 0.84 | IDH1 (0.37) | ATRSCN10ATSHRFSHRSYK | |
| SCHEMBL26152168 | 0.84 | CDK9 (0.36) | ATRSCN10ATSHRFSHRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405344-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | Xenon Pharmaceuticals Inc. (CA) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049369-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | XENON PHARMACEUTICALS INC. (CA) | 2023-03-30 | — | — | WO | disclosed |