Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 17/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168538 | 1.00 | KCNJ1 (0.49) | KCNJ1IRAK4CDK1KDR | |
| SCHEMBL20177023 | 0.84 | KCNJ1 (0.50) | KCNJ1IRAK4 | |
| SCHEMBL30444731 | 0.83 | KCNJ1 (0.51) | KCNJ1 | |
| SCHEMBL20575376 | 0.83 | KCNJ1 (0.51) | KCNJ1 | |
| SCHEMBL21850837 | 0.81 | KCNJ1 (0.51) | KCNJ1 | |
| SCHEMBL31023720 | 0.77 | EGLN1 (0.55) | — | |
| SCHEMBL30444710 | 0.77 | KCNJ1 (0.51) | KCNJ1IRAK4 | |
| SCHEMBL20168465 | 0.77 | KCNJ1 (0.51) | KCNJ1IRAK4 | |
| SCHEMBL31023519 | 0.75 | KDM4E (0.45) | KCNJ1 | |
| SCHEMBL20574774 | 0.74 | KCNJ1 (0.48) | KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139862-B | Substituted bicyclic heterocyclic derivatives useful as ROMK channel inhibitors | 百时美施贵宝公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-110678463-B | Substituted nitrogen-containing compounds | 百时美施贵宝公司 | 2023-06-06 | — | — | CN | disclosed |