Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 10/20 | 0.41 |
| ▸ | RARA | P10276 | 9/20 | 0.41 |
| ▸ | RARG | P13631 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 4/20 | 0.36 |
| ▸ | RXRB | P28702 | 2/20 | 0.36 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26152006 | 1.00 | RARB (0.41) | RARBRARARARGALDH1A1MAPK1 | |
| SCHEMBL26151991 | 0.85 | RARB (0.45) | RARBRARARARGPOLBRXRA | |
| SCHEMBL30445642 | 0.85 | RARB (0.45) | RARBRARARARGPOLBRXRA | |
| SCHEMBL26152005 | 0.84 | RARB (0.44) | RARBRARARARGALDH1A1MAPK1 | |
| SCHEMBL30445637 | 0.84 | RARB (0.44) | RARBRARARARGALDH1A1MAPK1 | |
| SCHEMBL21201892 | 0.75 | ALK (0.36) | RARBRARARARGALDH1A1MAPK1 | |
| SCHEMBL30133833 | 0.74 | MGAM (0.37) | RARBRARARARGALDH1A1MAPK1 | |
| SCHEMBL21201856 | 0.73 | ALK (0.35) | RARBRARARARGALDH1A1MAPK1 | |
| SCHEMBL31525543 | 0.71 | HTR2B (0.35) | ALDH1A1MAPK1KDM4EHSD17B10 | |
| SCHEMBL1021435 | 0.71 | RARB (0.56) | RARBRARARARGALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405344-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | Xenon Pharmaceuticals Inc. (CA) | 2024-07-31 | — | — | EP | disclosed |
| CN-118251389-A | Pyridyl derivatives as sodium channel activators | 泽农医药公司 | 2024-06-25 | — | — | CN | disclosed |
| WO-2023049369-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | XENON PHARMACEUTICALS INC. (CA) | 2023-03-30 | — | — | WO | disclosed |