Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 2/20 | 0.34 |
| ▸ | RARB | P10826 | 2/20 | 0.34 |
| ▸ | RARG | P13631 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21201856 | 0.83 | ALK (0.35) | ALKALDH1A1MAPK1RARARARB | |
| SCHEMBL21201881 | 0.83 | ALK (0.35) | ALKALDH1A1MAPK1HCAR3NNMT | |
| SCHEMBL21201891 | 0.79 | MEN1 (0.37) | ALKALDH1A1MAPK1PDE10AKDM4E | |
| SCHEMBL20797596 | 0.76 | PDE10A (0.35) | ALKPDE10A | |
| SCHEMBL21783039 | 0.75 | NNMT (0.42) | ALDH1A1MAPK1RARARARBRARG | |
| SCHEMBL30445352 | 0.75 | RARB (0.41) | ALDH1A1MAPK1RARARARBRARG | |
| SCHEMBL26152006 | 0.75 | RARB (0.41) | ALDH1A1MAPK1RARARARBRARG | |
| SCHEMBL21772931 | 0.75 | NNMT (0.38) | ALDH1A1RARARARBRARGRXRA | |
| SCHEMBL22225990 | 0.74 | KDM4E (0.36) | ALDH1A1RARARARBRARGRXRA | |
| SCHEMBL21783035 | 0.73 | NNMT (0.45) | ALDH1A1RARARARBRARGRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190263828-A1 | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-08-29 | — | — | US | disclosed |
| US-10364255-B2 | Heteroaromatic compounds as Vanin inhibitors | BOEHRINGER INGLEHEIM INTERNATIONAL GMBH (DE) | 2019-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263828-A1 | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | VHL, FANCI, UGT2B7 | ALK 1257/4885ALDH1A1 583/4885MAPK1 2518/4885 |
| US-10364255-B2 | Heteroaromatic compounds as Vanin inhibitors | VHL, FANCI, UGT2B7 | ALK 1257/4885ALDH1A1 583/4885MAPK1 2518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.