Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.35 |
| ▸ | CDK9 | P50750 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26152048 | 1.00 | TDP1 (0.37) | TDP1ATMABCC8KCNJ11CCNT1 | |
| SCHEMBL26152047 | 0.88 | TDP1 (0.36) | TDP1ATMABCC8KCNJ11CCNT1 | |
| SCHEMBL31058904 | 0.88 | TDP1 (0.36) | TDP1ATMABCC8KCNJ11CCNT1 | |
| SCHEMBL25679726 | 0.83 | TDP1 (0.39) | TDP1ATMABCC8KCNJ11CCNT1 | |
| SCHEMBL30445375 | 0.83 | TDP1 (0.39) | TDP1ATMABCC8KCNJ11CCNT1 | |
| SCHEMBL30445465 | 0.78 | ABCC8 (0.39) | TDP1ATMABCC8KCNJ11CCNT1 | |
| SCHEMBL26152041 | 0.78 | ABCC8 (0.39) | TDP1ATMABCC8KCNJ11CCNT1 | |
| SCHEMBL26152033 | 0.77 | CDC7 (0.37) | ALDH1A1LMNATGFBR1MAPK14PTPN1 | |
| SCHEMBL30419174 | 0.77 | CDC7 (0.37) | ALDH1A1LMNATGFBR1MAPK14PTPN1 | |
| SCHEMBL30444915 | 0.76 | CCNT1 (0.37) | TDP1ATMABCC8KCNJ11CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405344-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | Xenon Pharmaceuticals Inc. (CA) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049369-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | XENON PHARMACEUTICALS INC. (CA) | 2023-03-30 | — | — | WO | disclosed |