Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 12/20 | 0.79 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20974142 | 0.89 | ATF4 (1.00) | ATF4NPC1RAB9ATSHRNPSR1 | |
| SCHEMBL20973090 | 0.88 | ATF4 (0.81) | ATF4NPC1RAB9ATSHRNPSR1 | |
| SCHEMBL20722101 | 0.87 | ATF4 (0.75) | ATF4NPC1RAB9ATSHRNPSR1 | |
| SCHEMBL25639002 | 0.86 | ATF4 (0.57) | ATF4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL19555369 | 0.86 | ATF4 (0.83) | ATF4NPC1RAB9ATSHRNPSR1 | |
| SCHEMBL20722103 | 0.85 | ATF4 (0.77) | ATF4NPC1RAB9ATSHRNPSR1 | |
| Hydrochloric Acid SCHEMBL20610394 | 0.85 | ATF4 (0.81) | ATF4NPC1RAB9ATSHRNPSR1 | |
| SCHEMBL23357933 | 0.84 | ATF4 (0.75) | ATF4NPC1RAB9ATSHRNPSR1 | |
| SCHEMBL21618354 | 0.84 | ATF4 (0.79) | ATF4NPC1RAB9ATSHRNPSR1 | |
| SCHEMBL20610381 | 0.83 | ATF4 (0.89) | ATF4NPC1RAB9ATSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704089-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-19 | — | — | EP | disclosed |