Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29262977 | 1.00 | LMNA (0.42) | LMNAHRH4HRH3CTSLCTSB | |
| SCHEMBL25262482 | 0.83 | LMNA (0.43) | LMNAHRH4HRH3CTSLCTSB | |
| SCHEMBL29263037 | 0.83 | LMNA (0.43) | LMNAHRH4HRH3CTSLCTSB | |
| SCHEMBL31058889 | 0.83 | LMNA (0.43) | LMNAHRH4HRH3CTSLCTSB | |
| SCHEMBL14739617 | 0.80 | LMNA (0.45) | LMNAHRH4HRH3CTSLCTSB | |
| SCHEMBL28802203 | 0.76 | LMNA (0.47) | LMNAHRH4HRH3CTSLCTSB | |
| SCHEMBL524359 | 0.76 | LMNA (0.47) | LMNAHRH4HRH3CTSLCTSB | |
| SCHEMBL28802201 | 0.76 | LMNA (0.47) | LMNAHRH4HRH3CTSLCTSB | |
| SCHEMBL10420228 | 0.75 | LMNA (0.54) | LMNAHRH4HRH3CTSLCTSB | |
| SCHEMBL19559233 | 0.75 | LMNA (0.54) | LMNAHRH4HRH3CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405344-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | Xenon Pharmaceuticals Inc. (CA) | 2024-07-31 | — | — | EP | disclosed |
| CN-118251389-A | Pyridyl derivatives as sodium channel activators | 泽农医药公司 | 2024-06-25 | — | — | CN | disclosed |
| WO-2023049369-A2 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | XENON PHARMACEUTICALS INC. (CA) | 2023-03-30 | — | — | WO | disclosed |