Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.70 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.70 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.65 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10893588 | 0.92 | CHRNB2 (0.60) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL29187190 | 0.92 | CHRNB2 (0.65) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL3064618 | 0.90 | CHRNB2 (0.67) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL9262058 | 0.90 | CHRNB2 (0.62) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL13088099 | 0.87 | CHRNB2 (0.56) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL15921874 | 0.87 | CHRNB2 (0.64) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL3673693 | 0.87 | CHRNB2 (0.69) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL1841748 | 0.87 | CHRNB2 (0.64) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL10889195 | 0.86 | CHRNB2 (0.62) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL23014727 | 0.85 | CHRNB2 (0.57) | CHRNB2CHRNA4CYP2A6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9649301-B2 | Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-9649301-B2 | Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-9649301-B2 | Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-20150352088-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150352088-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2015-12-10 | — | — | US | disclosed |
| US-20140080859-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-20140080859-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-8653275-B2 | Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-02-18 | — | — | US | disclosed |
| US-8653275-B2 | Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-02-18 | — | — | US | disclosed |
| US-20100222377-A1 | BIS-QUATERNARY AMMONIUM CYCLOPHANE COMPOUNDS THAT INTERACT WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |
| US-20100222377-A1 | BIS-QUATERNARY AMMONIUM CYCLOPHANE COMPOUNDS THAT INTERACT WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080859-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | CHRNG, CHRNA10, CHRNA4 | CHRNB2 12/4885CHRNA4 3/4885CYP2A6 1405/4885 |
| US-20100222377-A1 | BIS-QUATERNARY AMMONIUM CYCLOPHANE COMPOUNDS THAT INTERACT WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNG, CHRNA10, CHRNA4 | CHRNB2 12/4885CHRNA4 3/4885CYP2A6 1405/4885 |
| US-20150352088-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | CHRNG, CHRNA10, CHRNA4 | CHRNB2 12/4885CHRNA4 3/4885CYP2A6 1405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.