Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.62 |
| ▸ | RAF1 | P04049 | 11/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28979423 | 1.00 | BRAF (0.62) | BRAFRAF1KDRFLT1FLT4 | |
| SCHEMBL30448879 | 0.87 | BRAF (0.57) | BRAFRAF1KDRFLT1FLT4 | |
| SCHEMBL28979418 | 0.87 | BRAF (0.57) | BRAFRAF1KDRFLT1FLT4 | |
| SCHEMBL28475724 | 0.86 | BRAF (0.70) | BRAFRAF1KDRFLT1FLT4 | |
| SCHEMBL29723089 | 0.84 | BRAF (0.65) | BRAFRAF1KDRFLT1FLT4 | |
| SCHEMBL28759795 | 0.84 | BRAF (0.65) | BRAFRAF1KDRFLT1FLT4 | |
| SCHEMBL30448881 | 0.80 | KDM1A (0.60) | BRAFRAF1KDRFLT1FLT4 | |
| SCHEMBL28473960 | 0.80 | KDM1A (0.60) | BRAFRAF1KDRFLT1FLT4 | |
| SCHEMBL30448179 | 0.79 | KDR (0.59) | BRAFRAF1KDRFLT1FLT4 | |
| SCHEMBL30447779 | 0.78 | KDR (0.68) | BRAFRAF1KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825605-B | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-03-31 | — | — | CN | disclosed |