Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 3/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30447715 | 0.90 | KDR (0.71) | KDRPDGFRACSF1RMETEGFR | |
| SCHEMBL28475724 | 0.86 | BRAF (0.70) | KDREGFRBRAFRAF1 | |
| SCHEMBL30448879 | 0.86 | BRAF (0.57) | KDRPDGFRAMETBRAFRAF1 | |
| SCHEMBL28979418 | 0.86 | BRAF (0.57) | KDRPDGFRAMETBRAFRAF1 | |
| SCHEMBL30448158 | 0.86 | MET (0.65) | KDRPDGFRACSF1RMETBRAF | |
| SCHEMBL30448257 | 0.85 | KDR (0.78) | KDRPDGFRACSF1RMETBRAF | |
| SCHEMBL28474019 | 0.85 | KDR (0.65) | KDRPDGFRACSF1RMETEGFR | |
| SCHEMBL30447669 | 0.85 | KDR (0.65) | KDRPDGFRACSF1RMETEGFR | |
| SCHEMBL28900930 | 0.84 | KDR (0.69) | KDRPDGFRACSF1RMETEGFR | |
| SCHEMBL30448368 | 0.83 | KDR (0.69) | KDRPDGFRACSF1RMETBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825605-B | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-03-31 | — | — | CN | disclosed |