Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20581180 | 1.00 | PDE4B (0.37) | PDE4BTLR9PDE4APDE4CPDE4D | |
| SCHEMBL20581215 | 0.96 | TLR9 (0.40) | PDE4BTLR9PDE4APDE4CPDE4D | |
| SCHEMBL20581236 | 0.92 | TLR9 (0.35) | PDE4BTLR9CCNT1CDK9JAK2 | |
| SCHEMBL20581099 | 0.84 | TLR9 (0.39) | TLR9CCNT1CDK9JAK2JAK1 | |
| SCHEMBL28371735 | 0.83 | QDPR (0.34) | PDE4BPDE4DCCNT1CDK9MAPK7 | |
| SCHEMBL20580702 | 0.83 | TLR9 (0.39) | TLR9CCNT1CDK9GPR119GABRG2 | |
| SCHEMBL20580937 | 0.83 | TLR9 (0.45) | PDE4BTLR9PDE4APDE4CPDE4D | |
| SCHEMBL20581226 | 0.82 | TLR9 (0.38) | TLR9GPR119GABRG2GABRB3GABRA5 | |
| SCHEMBL20580548 | 0.82 | TLR9 (0.45) | TLR9CCNT1CDK9GPR119GABRG2 | |
| SCHEMBL20581043 | 0.82 | EHMT2 (0.36) | PDE4BTLR9PDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634962-B1 | AZAINDOLE COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2023-05-24 | — | — | EP | disclosed |