SCHEMBL30451069

SCHEMBL30451069

COc1cc(-c2ncncc2-c2ccc(Br)cc2)cc(OC)c1OC

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.62
KMT2A Q03164 1/20 0.47
BRD4 O60885 1/20 0.44
NPSR1 Q6W5P4 1/20 0.43
IDO1 P14902 1/20 0.43
TDO2 P48775 1/20 0.43
LMNA P02545 1/20 0.43
HTT P42858 1/20 0.43
NCOA1 Q15788 1/20 0.42
NCOA3 Q9Y6Q9 1/20 0.42
CHEK2 O96017 1/20 0.42
FYN P06241 1/20 0.42
TUBB4A P04350 1/20 0.42
TUBB P07437 1/20 0.42
TUBA3C P0DPH7 1/20 0.42
TUBA1B P68363 1/20 0.42
TUBA4A P68366 1/20 0.42
TUBB4B P68371 1/20 0.42
TUBB3 Q13509 1/20 0.42
TUBB2A Q13885 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29014998 1.00 KCNH2 (0.62) KCNH2KMT2ABRD4NPSR1IDO1
SCHEMBL29014967 0.88 KCNH2 (0.63) KCNH2KMT2ANPSR1LMNAHTT
SCHEMBL30451554 0.88 KCNH2 (0.63) KCNH2KMT2ANPSR1LMNAHTT
SCHEMBL30450312 0.84 KCNH2 (0.66) KCNH2KMT2ABRD4FYN
SCHEMBL29014996 0.84 KCNH2 (0.66) KCNH2KMT2ABRD4FYN
SCHEMBL30450950 0.84 KCNH2 (0.60) KCNH2KMT2ABRD4NPSR1LMNA
SCHEMBL29015021 0.84 KCNH2 (0.60) KCNH2KMT2ABRD4NPSR1LMNA
SCHEMBL30450585 0.83 KCNH2 (0.71) KCNH2KMT2ANPSR1LMNAHTT
SCHEMBL29015012 0.83 KCNH2 (0.71) KCNH2KMT2ANPSR1LMNAHTT
SCHEMBL30451354 0.83 KCNH2 (0.58) KCNH2KMT2ABRD4NPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116253687-A Diaryl pyrimidine compound and preparation method and application thereof 复旦大学 2023-06-13 CN disclosed