Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257500 | 1.00 | AKR1C3 (0.42) | AKR1C3AKR1C2NPC1RAB9ACYP1A2 | |
| SCHEMBL30546878 | 0.86 | AKR1C3 (0.41) | AKR1C3AKR1C2NPC1RAB9ACYP1A2 | |
| SCHEMBL30454632 | 0.84 | EGLN1 (0.48) | — | |
| SCHEMBL24257501 | 0.84 | EGLN1 (0.48) | — | |
| SCHEMBL30453199 | 0.84 | MCL1 (0.53) | AKR1C3AKR1C2NPC1RAB9APOLB | |
| SCHEMBL24257774 | 0.84 | MCL1 (0.53) | AKR1C3AKR1C2NPC1RAB9APOLB | |
| Nitrous Acid SCHEMBL29248977 | 0.83 | DHODH (0.40) | AKR1C3AKR1C2NPC1RAB9ACYP1A2 | |
| SCHEMBL24257702 | 0.80 | AR (0.45) | ABL1 | |
| SCHEMBL30453303 | 0.80 | AR (0.45) | ABL1 | |
| SCHEMBL24257684 | 0.79 | NPC1 (0.43) | AKR1C3AKR1C2NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |