Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257743 | 1.00 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1EPHX1KMT2A | |
| SCHEMBL30546817 | 0.88 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP19A1EPHX1KMT2A | |
| SCHEMBL29248901 | 0.88 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP19A1EPHX1KMT2A | |
| SCHEMBL24257759 | 0.87 | KDM4E (0.42) | LMNAKDM4EALDH1A1 | |
| SCHEMBL24257668 | 0.85 | FFAR1 (0.43) | LMNATDP1 | |
| SCHEMBL24257585 | 0.83 | PTGER1 (0.47) | — | |
| SCHEMBL30454075 | 0.83 | PTGER1 (0.47) | — | |
| SCHEMBL24257669 | 0.83 | C5AR1 (0.43) | TDP1 | |
| SCHEMBL30453291 | 0.83 | C5AR1 (0.43) | TDP1 | |
| SCHEMBL24257514 | 0.83 | ALDH1A1 (0.48) | CYP11B1CYP11B2CYP19A1EPHX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |