SCHEMBL30452838

SCHEMBL30452838

C=CC(CC(=O)Nc1ccc(I)c2cccnc12)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.41
TP53 P04637 2/20 0.41
KDR P35968 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
POLB P06746 1/20 0.37
RPS6KB1 P23443 1/20 0.37
ALDH1A1 P00352 4/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
KDM4E B2RXH2 2/20 0.37
MAPT P10636 2/20 0.37
MEN1 O00255 3/20 0.37
HPGD P15428 2/20 0.37
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29196758 0.84 TDP1 (0.41) KMT2ATP53TDP1POLBALDH1A1
SCHEMBL31405280 0.79 TDP1 (0.48) KMT2ATP53KDRTDP1POLB
SCHEMBL29196759 0.78 POLB (0.44) KMT2ATP53TDP1POLBALDH1A1
SCHEMBL31405301 0.77 RPS6KB1 (0.42) KMT2ATP53KDRTDP1RPS6KB1
SCHEMBL28891850 0.76 KDR (0.63) KMT2ATP53KDRTDP1ALDH1A1
SCHEMBL30452785 0.76 TDP1 (0.41) KMT2ATP53TDP1POLBALDH1A1
SCHEMBL29196775 0.76 HTT (0.46) KMT2ATP53TDP1POLBSMN1; SMN2
SCHEMBL31405300 0.75 KMT2A (0.40) KMT2ATP53TDP1POLBALDH1A1
SCHEMBL31411238 0.75 RPS6KB1 (0.40) KMT2ATP53KDRRPS6KB1ALDH1A1
SCHEMBL31405272 0.75 KMT2A (0.38) KMT2ATP53TDP1POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116283765-A Chlorotrifluoromethylation method of inactive olefin 苏州大学 2023-06-23 CN disclosed