SCHEMBL30453004 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	RET	P07949	18/20	0.61

▸	KDM4E	B2RXH2	1/20	0.47

▸	ALDH1A1	P00352	1/20	0.47

▸	HPGD	P15428	1/20	0.47

▸	HSD17B10	Q99714	1/20	0.47

▸	JAK2	O60674	1/20	0.46

▸	FLT3	P36888	1/20	0.46

▸	AURKA	O14965	1/20	0.45

▸	AURKB	Q96GD4	1/20	0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29016163	1.00	RET (0.61)	RETKDM4EALDH1A1HPGDHSD17B10
SCHEMBL30453270	0.89	RET (0.61)	RETJAK2AURKAAURKB
SCHEMBL30452755	0.86	RET (0.56)	RETJAK2FLT3
SCHEMBL28429868	0.86	RET (0.56)	RETJAK2FLT3
Hydrochloric Acid SCHEMBL30453172	0.81	RET (0.59)	RETJAK2FLT3
Hydrochloric Acid SCHEMBL28434225	0.81	RET (0.59)	RETJAK2FLT3
SCHEMBL22041676	0.81	RET (0.55)	RETALDH1A1JAK2FLT3
SCHEMBL19796299	0.80	RET (0.73)	RET
SCHEMBL22041785	0.80	RET (0.55)	RETJAK2FLT3
SCHEMBL21744951	0.79	RET (0.60)	RETJAK2AURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-111484479-B	Azacyclic compounds, pharmaceutical compositions containing the same, and methods of making and using the same	四川科伦博泰生物医药股份有限公司	2023-06-13	—	—	CN	disclosed