Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 4/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257621 | 1.00 | MCL1 (0.44) | MCL1MRGPRX4ALOX5DHODHP2RY14 | |
| SCHEMBL24257684 | 0.88 | NPC1 (0.43) | MCL1DHODHMEN1KMT2A | |
| SCHEMBL30452976 | 0.88 | NPC1 (0.43) | MCL1DHODHMEN1KMT2A | |
| Nitrous Acid SCHEMBL29248926 | 0.86 | NPC1 (0.41) | MCL1DHODHEGLN1MEN1KMT2A | |
| SCHEMBL24257668 | 0.85 | FFAR1 (0.43) | MRGPRX4DHODHP2RY14EGLN1 | |
| SCHEMBL24257759 | 0.85 | KDM4E (0.42) | MCL1DHODHP4HTM | |
| SCHEMBL30453121 | 0.84 | MAOB (0.47) | MRGPRX4DHODHKMT2A | |
| SCHEMBL24257539 | 0.84 | MCL1 (0.44) | MCL1MRGPRX4DHODH | |
| SCHEMBL24257685 | 0.84 | MAOB (0.47) | MRGPRX4DHODHKMT2A | |
| SCHEMBL24257792 | 0.83 | EGLN1 (0.46) | FTOEGLN1EGLN3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |