Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 16/20 | 0.43 |
| ▸ | VEGFA | P15692 | 4/20 | 0.43 |
| ▸ | FLT1 | P17948 | 4/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | STAMBP | O95630 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26260159 | 0.92 | SMN1; SMN2 (0.39) | EGLN1VEGFAFLT1EGLN3KDM4E | |
| SCHEMBL24257625 | 0.79 | ALDH1A1 (0.39) | EGLN1VEGFAFLT1EGLN3KDM4E | |
| SCHEMBL26260156 | 0.78 | SMN1; SMN2 (0.37) | EGLN1VEGFAFLT1EGLN3KDM4E | |
| SCHEMBL26260138 | 0.76 | SMN1; SMN2 (0.43) | EGLN1VEGFAFLT1EGLN3KDM4E | |
| SCHEMBL26263986 | 0.75 | EGLN1 (0.44) | EGLN1VEGFAFLT1EGLN3GAA | |
| SCHEMBL24257755 | 0.71 | EGLN1 (0.55) | EGLN1VEGFAFLT1EGLN3KDM4E | |
| SCHEMBL26260298 | 0.70 | EGLN1 (0.48) | EGLN1VEGFAFLT1EGLN3KDM4E | |
| SCHEMBL26260139 | 0.69 | EGLN1 (0.42) | EGLN1VEGFAFLT1EGLN3GAA | |
| SCHEMBL30452393 | 0.68 | SMN1; SMN2 (0.38) | EGLN1VEGFAFLT1EGLN3GAA | |
| SCHEMBL26260152 | 0.68 | ALDH1A1 (0.41) | EGLN1VEGFAFLT1EGLN3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |