Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | MAT2A | P31153 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257586 | 1.00 | NPC1 (0.41) | NPC1RAB9ACLK1CLK2DYRK1A | |
| SCHEMBL24257690 | 0.88 | CNR1 (0.39) | CNR1CSF1R | |
| SCHEMBL30452359 | 0.88 | CNR1 (0.39) | CNR1CSF1R | |
| SCHEMBL30453284 | 0.85 | CYP11B1 (0.43) | CNR1MAPT | |
| SCHEMBL24257729 | 0.85 | CYP11B1 (0.43) | CNR1MAPT | |
| SCHEMBL30546866 | 0.82 | CLK1 (0.46) | NPC1RAB9ACLK1CLK2DYRK1A | |
| SCHEMBL24257819 | 0.81 | HSD17B10 (0.43) | RAB9ACNR1ADORA2AMAPTPOLB | |
| SCHEMBL30546879 | 0.81 | HSD17B10 (0.43) | RAB9ACNR1ADORA2AMAPTPOLB | |
| Nitrous Acid SCHEMBL29248965 | 0.80 | CLK1 (0.44) | NPC1RAB9ACLK1CLK2DYRK1A | |
| SCHEMBL29248962 | 0.79 | CLK1 (0.43) | NPC1RAB9ACLK1CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |