Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257744 | 1.00 | KDM4E (0.43) | KDM4EKMT2AKDM6BKDM4AKDM5C | |
| SCHEMBL24257547 | 0.82 | EGLN2 (0.50) | — | |
| SCHEMBL30546844 | 0.82 | EGLN2 (0.50) | — | |
| SCHEMBL25529048 | 0.77 | KDM4E (0.46) | KDM4EKMT2AKDM6BKDM4AKDM5C | |
| SCHEMBL30546867 | 0.76 | LMNA (0.50) | KDM4ELMNAL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL24257683 | 0.76 | LMNA (0.50) | KDM4ELMNAL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL30453015 | 0.76 | LMNA (0.50) | KDM4ELMNAL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL24257694 | 0.76 | FYN (0.40) | NAPRTERN1 | |
| SCHEMBL30546823 | 0.76 | FYN (0.40) | NAPRTERN1 | |
| SCHEMBL3387695 | 0.76 | KDM4E (0.44) | KDM4EKMT2AKDM6BKDM4AKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |