Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.39 |
| ▸ | MERTK | Q12866 | 3/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719617 | 0.87 | NAMPT (0.41) | NAMPTHDAC1SYKFLT3TYRO3 | |
| SCHEMBL3054183 | 0.85 | NAMPT (0.52) | NAMPTHDAC1PDE4BCYP2C9 | |
| SCHEMBL3048802 | 0.82 | NAMPT (0.52) | NAMPTHDAC1CYP2C9 | |
| SCHEMBL3050217 | 0.81 | HDAC1 (0.47) | NAMPTHDAC1SYKFLT3TYRO3 | |
| SCHEMBL3052778 | 0.79 | HDAC1 (0.45) | NAMPTHDAC1FLT3TYRO3MERTK | |
| SCHEMBL3042675 | 0.79 | NAMPT (0.45) | NAMPTHDAC1SYKFLT3TYRO3 | |
| SCHEMBL3048653 | 0.77 | TYRO3 (0.51) | FLT3TYRO3MERTKGAS6 | |
| SCHEMBL3046675 | 0.74 | NAMPT (0.46) | NAMPTHDAC1FLT3TYRO3MERTK | |
| SCHEMBL3722076 | 0.74 | HDAC1 (0.47) | NAMPTHDAC1PDE4B | |
| SCHEMBL874763 | 0.73 | NAMPT (0.43) | NAMPTHDAC1SYKFLT3TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222319-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-02 | — | — | US | claimed |
| US-20100222319-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-02 | — | — | US | disclosed |
| EP-2205566-A2 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009074749-A2 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222319-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | NNT, NAMPT, NQO1 | NAMPT 2/4885HDAC1 84/4885PDE4B 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.