Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.38 |
| ▸ | MERTK | Q12866 | 2/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875487 | 0.88 | HDAC1 (0.45) | NAMPTHDAC1ROCK2ALDH1A1POLB | |
| SCHEMBL875947 | 0.86 | PPARA (0.49) | NAMPTHDAC1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL875702 | 0.82 | NAMPT (0.44) | NAMPTHDAC1ROCK2ALDH1A1POLB | |
| SCHEMBL875577 | 0.77 | HDAC1 (0.43) | NAMPTHDAC1FLT3TYRO3MERTK | |
| SCHEMBL875591 | 0.77 | NAMPT (0.46) | NAMPTHDAC1PPARA | |
| SCHEMBL874755 | 0.76 | NAMPT (0.47) | NAMPTHDAC1POLB | |
| SCHEMBL874757 | 0.76 | HDAC1 (0.44) | NAMPTHDAC1ROCK2 | |
| SCHEMBL3050217 | 0.76 | HDAC1 (0.47) | NAMPTHDAC1FLT3TYRO3MERTK | |
| SCHEMBL874752 | 0.75 | NAMPT (0.52) | NAMPTHDAC1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3048653 | 0.75 | TYRO3 (0.51) | FLT3TYRO3MERTKGAS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |