Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7920632 | 0.80 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2HSD17B10PDE10A | |
| SCHEMBL20605163 | 0.77 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2HSD17B10PDE10A | |
| SCHEMBL9615525 | 0.77 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2HSD17B10PDE10A | |
| SCHEMBL15774157 | 0.77 | PIK3CG (0.47) | KDM4EALDH1A1SMN1; SMN2PDE10ATP53 | |
| SCHEMBL25097481 | 0.77 | KCNH2 (0.36) | KDM4EALDH1A1SMN1; SMN2PDE10ANPC1 | |
| SCHEMBL10271751 | 0.74 | PDE10A (0.40) | KDM4EALDH1A1SMN1; SMN2PDE10ATP53 | |
| SCHEMBL10220101 | 0.74 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2HSD17B10PDE10A | |
| SCHEMBL15938473 | 0.72 | CYP11B2 (0.45) | PDE10AMAPK14AHRCYP11B1CYP11B2 | |
| SCHEMBL19167338 | 0.72 | PDE10A (0.60) | SMN1; SMN2PDE10ATP53NPC1RAB9A | |
| SCHEMBL7851412 | 0.72 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2HSD17B10PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183237-A1 | COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 | VANDERBILT UNIVERSITY | 2023-06-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183237-A1 | COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 | CHRM5, CHRM1, CHRM2 | KDM4E 1188/4885ALDH1A1 622/4885SMN1; SMN2 3044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.