Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 5/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30995473 | 0.85 | BTK (0.45) | BTKJAK1KDM1AMAOBJAK2 | |
| SCHEMBL22241872 | 0.85 | KDM1A (0.46) | BTKJAK1KDM1AMAOBJAK2 | |
| SCHEMBL30842076 | 0.85 | BTK (0.41) | BTKJAK1KDM1AMAOBJAK2 | |
| SCHEMBL22406211 | 0.83 | PCSK9 (0.50) | BTKJAK1KDM1AMAOBJAK2 | |
| SCHEMBL22241734 | 0.83 | PCSK9 (0.50) | BTKJAK1KDM1AMAOBJAK2 | |
| SCHEMBL30842050 | 0.83 | JAK1 (0.42) | BTKJAK1KDM1AMAOBJAK2 | |
| SCHEMBL25360845 | 0.82 | BTK (0.43) | BTKJAK1KDM1AMAOBJAK2 | |
| SCHEMBL30456486 | 0.82 | BTK (0.43) | BTKJAK1KDM1AMAOBJAK2 | |
| SCHEMBL30827611 | 0.82 | BTK (0.44) | BTKJAK1KDM1AMAOBJAK2 | |
| SCHEMBL27252132 | 0.82 | BTK (0.44) | BTKJAK1KDM1AMAOBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116761-A1 | PYRIMIDINE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 英矽智能科技知识产权有限公司 | 2023-06-29 | — | — | WO | disclosed |