Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 9/20 | 0.47 |
| ▸ | GRM5 | P41594 | 9/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25723290 | 1.00 | GRM1 (0.47) | GRM1GRM5KDM1ACYP11B2TNK2 | |
| SCHEMBL20135287 | 0.87 | GRM1 (0.52) | GRM1GRM5CYP11B2TNK2PDK4 | |
| SCHEMBL25226634 | 0.85 | LIMK1 (0.46) | LIMK1LIMK2 | |
| SCHEMBL15168000 | 0.84 | TNK2 (0.50) | GRM1GRM5CYP11B2TNK2PDK4 | |
| SCHEMBL30899649 | 0.84 | GRM1 (0.49) | GRM1GRM5CYP11B2TNK2PDK4 | |
| SCHEMBL15167800 | 0.84 | GRM1 (0.49) | GRM1GRM5CYP11B2TNK2PDK4 | |
| SCHEMBL30366133 | 0.84 | GRM1 (0.49) | GRM1GRM5CYP11B2TNK2PDK4 | |
| SCHEMBL31533241 | 0.82 | GRM1 (0.49) | GRM1GRM5CYP11B2TNK2PDK4 | |
| SCHEMBL25237973 | 0.82 | GRM1 (0.49) | GRM1GRM5CYP11B2TNK2PDK4 | |
| SCHEMBL12686706 | 0.81 | GRM1 (0.53) | GRM1GRM5KDM1APDK4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183237-A1 | COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 | VANDERBILT UNIVERSITY | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183237-A1 | COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 | CHRM5, CHRM1, CHRM2 | GRM1 30/4885GRM5 21/4885KDM1A 1238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.