Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 10/20 | 0.49 |
| ▸ | GRM5 | P41594 | 9/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
| ▸ | GABRE | P78334 | 1/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30899649 | 1.00 | GRM1 (0.49) | GRM1GRM5CNR1PDK4CYP11B2 | |
| SCHEMBL31583898 | 0.90 | GRM1 (0.55) | GRM1GRM5CNR1PDK4CYP11B2 | |
| SCHEMBL20135287 | 0.90 | GRM1 (0.52) | GRM1GRM5PDK4CYP11B2TNK2 | |
| SCHEMBL74150 | 0.88 | TNK2 (0.49) | GRM1GRM5CNR1PDK4CYP11B2 | |
| SCHEMBL15168000 | 0.87 | TNK2 (0.50) | GRM1GRM5PDK4CYP11B2TNK2 | |
| SCHEMBL15167800 | 0.87 | GRM1 (0.49) | GRM1GRM5PDK4CYP11B2TNK2 | |
| SCHEMBL25237973 | 0.85 | GRM1 (0.49) | GRM1GRM5PDK4CYP11B2TNK2 | |
| SCHEMBL31533241 | 0.85 | GRM1 (0.49) | GRM1GRM5PDK4CYP11B2TNK2 | |
| SCHEMBL25723290 | 0.84 | GRM1 (0.47) | GRM1GRM5PDK4CYP11B2TNK2 | |
| SCHEMBL30456775 | 0.84 | GRM1 (0.47) | GRM1GRM5PDK4CYP11B2TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405051-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023046806-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-30 | — | — | WO | disclosed |