SCHEMBL30457735

SCHEMBL30457735

COc1ccc(-c2cnc3n2CCN(C(=O)OC(C)(C)C)C3)cc1C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 2/20 0.47
PDK2 Q15119 1/20 0.46
NR1H2 P55055 1/20 0.43
P2RX7 Q99572 8/20 0.42
TTK P33981 1/20 0.40
SMPD3 Q9NY59 2/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
CRHBP P24387 1/20 0.39
HTT P42858 1/20 0.39
KMT2A Q03164 1/20 0.39
CRHR2 Q13324 1/20 0.39
HSD17B10 Q99714 1/20 0.39
PIK3CD O00329 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25275872 1.00 CFTR (0.47) CFTRPDK2NR1H2P2RX7TTK
SCHEMBL15519766 0.86 CFTR (0.48) CFTRPDK2NR1H2P2RX7TTK
SCHEMBL29575643 0.78 PDK2 (0.50) PDK2NR1H2P2RX7HDAC4HDAC1
SCHEMBL16836088 0.76 MTOR (0.47) PDK2P2RX7HDAC4HDAC1HDAC6
SCHEMBL28886725 0.75 PDK2 (0.47) PDK2NR1H2P2RX7TTKPIK3CD
SCHEMBL10095054 0.74 PDK2 (0.48) PDK2NR1H2P2RX7
SCHEMBL19611104 0.74 P2RX7 (0.46) PDK2P2RX7HDAC4HDAC1HDAC6
SCHEMBL23549881 0.74 P2RX7 (0.44) PDK2NR1H2P2RX7HDAC4HDAC1
SCHEMBL28887447 0.74 NR1H2 (0.49) PDK2NR1H2ALDH1A1CKS1BSKP1
SCHEMBL18149094 0.73 PDK2 (0.42) PDK2NR1H2P2RX7HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4448500-A1 BENZOTHIAZOLE, BENZOISOXAZOLE AND BENZODIOXOLE ANALOGS AS RXFP1 RECEPTOR AGONISTS Bristol-Myers Squibb Company (US) 2024-10-23 EP disclosed
CN-118401502-A Benzothiazole, benzisoxazole and benzodioxole analogs as RXFP1 receptor agonists 百时美施贵宝公司 2024-07-26 CN disclosed
WO-2023114822-A1 BENZOTHIAZOLE, BENZOISOXAZOLE AND BENZODIOXOLE ANALOGS AS RXFP1 RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2023-06-22 WO disclosed