Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.53 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.39 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.38 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 3/20 | 0.36 |
| ▸ | IL1B | P01584 | 3/20 | 0.36 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30460123 | 0.92 | CRBN (0.53) | CRBNIKZF3DDB1IKZF2GSPT1 | |
| SCHEMBL30459375 | 0.91 | CRBN (0.54) | CRBNIKZF3DDB1IKZF2TNF | |
| SCHEMBL30459357 | 0.88 | CRBN (0.53) | CRBNIKZF3DDB1IKZF2GSPT1 | |
| SCHEMBL30458369 | 0.85 | CRBN (0.49) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL30458263 | 0.84 | CRBN (0.55) | CRBNIKZF3DDB1IKZF2TNF | |
| SCHEMBL30458385 | 0.83 | CRBN (0.54) | CRBNIKZF3DDB1IKZF2 | |
| SCHEMBL25228108 | 0.83 | CRBN (0.57) | CRBNIKZF3DDB1IKZF2TNF | |
| SCHEMBL31077119 | 0.83 | CRBN (0.57) | CRBNIKZF3DDB1IKZF2TNF | |
| SCHEMBL30459878 | 0.82 | CRBN (0.53) | CRBNIKZF3DDB1IKZF2TNF | |
| SCHEMBL30459729 | 0.82 | CRBN (0.53) | CRBNIKZF3DDB1IKZF2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | claimed |