Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.37 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | IL1B | P01584 | 1/20 | 0.36 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.36 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30458369 | 0.93 | CRBN (0.49) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL30460123 | 0.92 | CRBN (0.53) | CRBNDDB1GSPT1IKZF3IKZF1 | |
| SCHEMBL30458739 | 0.88 | CRBN (0.53) | CRBNDDB1GSPT1IKZF3BRD4 | |
| SCHEMBL30459375 | 0.85 | CRBN (0.54) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL30460136 | 0.84 | CRBN (0.57) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL30458968 | 0.84 | CRBN (0.57) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL25647443 | 0.83 | CRBN (0.57) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL30458263 | 0.82 | CRBN (0.55) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL30458935 | 0.81 | CRBN (0.51) | CRBNDDB1GSPT1IKZF3IKZF1 | |
| SCHEMBL25423114 | 0.81 | CRBN (0.65) | CRBNDDB1IKZF3BRD4TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | claimed |