Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.59 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.44 |
| ▸ | TYMS | P04818 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | FABP6 | P51161 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475799 | 0.81 | PARP1 (0.68) | PARP1PARP10SRD5A1ACHEFABP6 | |
| SCHEMBL30524061 | 0.81 | PARP1 (0.68) | PARP1PARP10SRD5A1ACHEFABP6 | |
| SCHEMBL29914810 | 0.74 | PARP10 (1.00) | PARP1PARP10SRD5A1FABP6GRM5 | |
| SCHEMBL23952279 | 0.74 | PARP10 (1.00) | PARP1PARP10SRD5A1FABP6GRM5 | |
| SCHEMBL30268443 | 0.74 | NTRK2 (0.35) | PARP1PARP10NTRK2TYRO3CLK4 | |
| SCHEMBL29376253 | 0.72 | CA12 (0.63) | PARP1PARP10SRD5A1ACHETDP2 | |
| SCHEMBL15154660 | 0.72 | CA12 (0.63) | PARP1PARP10SRD5A1ACHETDP2 | |
| SCHEMBL22904532 | 0.70 | TDP2 (0.65) | PARP1PARP10TDP2 | |
| SCHEMBL5518824 | 0.70 | PARP1 (0.58) | PARP1PARP10SRD5A1TYMSACHE | |
| SCHEMBL29443089 | 0.68 | PBRM1 (0.59) | PARP1PARP10SRD5A1TYMSACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |