Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683307 | 1.00 | EGFR (0.59) | EGFRMKNK2MKNK1DYRK3IGF1R | |
| SCHEMBL18607255 | 0.91 | EGFR (0.48) | EGFRMKNK2DYRK3IGF1RCDK2 | |
| SCHEMBL29973838 | 0.91 | EGFR (0.70) | EGFRMKNK2MKNK1DYRK3IGF1R | |
| SCHEMBL14663321 | 0.91 | EGFR (0.70) | EGFRMKNK2MKNK1DYRK3IGF1R | |
| SCHEMBL30459797 | 0.87 | EGFR (0.61) | EGFRMKNK2MKNK1DYRK3IGF1R | |
| SCHEMBL17683250 | 0.87 | EGFR (0.61) | EGFRMKNK2MKNK1DYRK3IGF1R | |
| SCHEMBL17683074 | 0.87 | EGFR (0.54) | EGFRMKNK2MKNK1FLT3 | |
| SCHEMBL30460067 | 0.87 | EGFR (0.54) | EGFRMKNK2MKNK1FLT3 | |
| SCHEMBL30460261 | 0.85 | EGFR (0.61) | EGFRMKNK2MKNK1DYRK3IGF1R | |
| SCHEMBL19337188 | 0.85 | EGFR (0.70) | EGFRMKNK2MKNK1DYRK3IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |