Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30539153 | 0.91 | EGFR (0.61) | EGFRFLT3IGF1RKCNH2MKNK2 | |
| SCHEMBL30459797 | 0.86 | EGFR (0.61) | EGFRFLT3IGF1RKCNH2MKNK2 | |
| SCHEMBL17683250 | 0.86 | EGFR (0.61) | EGFRFLT3IGF1RKCNH2MKNK2 | |
| SCHEMBL30459692 | 0.85 | EGFR (0.59) | EGFRFLT3IGF1RMKNK2MKNK1 | |
| SCHEMBL17683307 | 0.85 | EGFR (0.59) | EGFRFLT3IGF1RMKNK2MKNK1 | |
| SCHEMBL17683244 | 0.84 | EGFR (0.84) | EGFRIGF1RKCNH2MLNRKDM1A | |
| SCHEMBL30459884 | 0.84 | EGFR (0.84) | EGFRIGF1RKCNH2MLNRKDM1A | |
| SCHEMBL30459855 | 0.81 | EGFR (0.57) | EGFRIGF1RKCNH2MKNK2MKNK1 | |
| SCHEMBL20357527 | 0.81 | EGFR (0.41) | EGFRKCNH2MKNK2MKNK1MLNR | |
| SCHEMBL18607262 | 0.77 | EGFR (0.49) | EGFRFLT3IGF1RKCNH2MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |